Straightforward access to linear and cyclic polypeptides
نویسندگان
چکیده
منابع مشابه
Straightforward synthesis of cyclic and bicyclic peptides.
Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected mal...
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A new tandem catalytic system mediates very efficiently and selectively at room temperature two sequential reactions to produce relevant derivatives in one pot. Remarkably, this new concept of catalysis allows the facile synthesis of polypeptides and provides direct access to cyclic carbonates in high yields, through the incorporation of the carbon dioxide released from the initial step, thus a...
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A zwitterion, generated from an aryne and an imine, has been demonstrated to serve as an excellent molecular scaffold for capturing CO2, which results in the straightforward formation of diverse benzoxazinones.
متن کاملEmerging strategies to access peptide macrocycles from genetically encoded polypeptides.
Macrocyclic peptides have emerged as attractive molecular scaffolds for the development of chemical probes and therapeutics. In this synopsis, we highlight contemporary strategies to access peptide macrocycles from ribosomally produced polypeptides. Challenges that have been tackled in this area involve orchestrating the desired macrocyclization process in the presence of unprotected polypeptid...
متن کاملAn Introduction to Linear and Cyclic Codes
We shall examine a small aspect of coding theory from an algebraic standpoint, examining the algorithms for decoding and encoding from a theoretical perspective. We assume basic knowledge of finite fields, but we shall introduce the theory of linear codes and built up to the machinery for generating cyclic codes and efficiently encoding and decoding them.
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ژورنال
عنوان ژورنال: Communications Chemistry
سال: 2018
ISSN: 2399-3669
DOI: 10.1038/s42004-018-0040-0